This workshop will review scientific principles and risk-based methodologies for assessing cumulative health risk from exposure to chemical mixtures, including descriptions of current methods and the introduction of state-of-the-art approaches.
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This half-day workshop presents scientific principles and risk based methodologies for assessing cumulative health risk from exposure to chemical mixtures, including descriptions of current methods, discussions of the mechanistic basis for interaction effects, and the introduction of state-of-the-art approaches. Humans are typically exposed to chemical mixtures via irregular exposure patterns and variable doses. In recognition of this, the United States Environmental Protection Agency, Agency for Toxic Substances and Disease Registry, National Institute of Occupational Safety and Health, National Center for Toxicological Research and others have conducted research since the early 1980s to develop chemical mixture health risk assessment methods and assessments. More recently, the Food Quality Protection Act and Safe Drinking Water Act Amendments were passed in 1996, raising awareness of chemical mixtures health issues. This workshop presents chemical mixture health risk assessment topics including: procedures and definitions for use in selecting among risk assessment methods; component-based approaches: response-addition, dose addition, relative potency factors; procedures using whole mixture data; and approaches for incorporating toxicological interactions data. The content of this workshop includes a general overview of chemical mixture health risk assessment data evaluation and procedures, a discussion of the mechanistic bases for toxicological interactions; a detailed description of several new methods, and hands-on exercises with test data sets. Discussions include real world examples, exercise results, issues for application of the procedures, and general questions and comments. Participants are asked to bring a calculator. This course is for anyone interested in chemical mixtures risk assessment. However, basic knowledge of this area is helpful, (e.g., understanding of additivity concepts, application of the Hazard Index, etc.) An overview of the basic tenets and scientific principles will be given, but emphasis will be on additional development of these tenets and presentation of new ideas and approaches.
Linda K. Teuschler has been a Mathematical Statistician with United States Environmental Protection Agency’s (EPA) Office of Research and Development, National Center for Environmental Assessment since November 1989. She received a M.S. in Mathematics from the University of Cincinnati in 1987. Her specific area of expertise is the development of chemical mixtures health risk assessment methodologies, the technical transfer of these risk assessment methods through the development of guidance documents and publications, and the application of such methods to the risk assessment of mixtures of drinking water disinfection by-products (DBPs) and other contaminant mixtures. She served on EPA's Risk Assessment Forum Technical Panel that recently authored and published the 2000 Supplementary Guidance for the Health Risk Assessment of Chemical Mixtures. She has actively published in the scientific literature, primarily contributing to the development of risk assessment methods for both single chemicals (e.g., dose-response modeling of risk, evaluation of uncertainty factor magnitudes, approaches for combining data sets in evaluating cancer data) and for chemical mixtures (e.g., efficient experimental designs for mixture toxicology studies, methods for estimating health risks from exposure to DBP mixtures, dose-response modeling for mixtures, screening assays for DBP mixtures, innovative mixture risk assessment methods, comparison of DBP mixture health risks with those of microbial agents). She is a member of the Society for Risk Analysis and the American Statistical Association.
Dr. Moiz Mumtaz has worked as Science Advisor for the Research Implementation Branch, Division of Toxicology, Agency for Toxic Substances and Disease Registry (ATSDR), since August 1992. His involvement in several agencywide activities has led to a) the establishment of a mixtures research program for determining significant human exposures to environmental chemicals, b) the establishment of a computational toxicology laboratory for characterizing the behavior of chemicals after they enter the human body or estimating the toxicity of chemicals based on structure-activity relationships (SAR), and c) the revision of ATSDR guidelines and policy for clearing publications. Dr. Mumtaz obtained his Ph.D. in toxicology from the University of Maryland and received his M.S. in chemistry/entomology from Oregon State University. He also has an M.S. in analytical chemistry from Osmania University, India. Dr. Mumtaz has actively published his research findings in several peer-reviewed journals during the past two decades. These publications have covered a wide range of research areas pertinent to medicine and human health that included but were not limited to dopamine metabolism and mental health, chemical analysis of xenobiotics and environmental chemicals, and health risk assessment of chemicals and susceptible human populations. Dr. Mumtaz is a full member of the Society of Toxicology, the Association of Government Toxicologists, the American Chemical Society -- Pesticide Division, the American Society of Pharmacology and Experimental Therapeutics, and the Association of State and Territorial Risk Assessors.
Rick Hertzberg has been a Mathematical Statistician with United States Environmental Protection Agency’s (EPA) Office of Research and Development, National Center for Environmental Assessment since November 1980. He received his Ph.D. in Biomathematics in 1977 from the University of Washington, Seattle. Rick is the primary author of both the EPA’s 1986 Mixtures Guidelines and 2001 Supplementary Guidance for the Health Risk Assessment of Chemical Mixtures, and chaired both workgroups that developed those reports. Recently, he has worked on EPA’s Office of Pesticide Programs' Cumulative Risk Work Group, EPA's Risk Assessment Forum cumulative risk technical panel, and external advisory groups on mixture risk for ATSDR, NIOSH and the Dutch Health Council. He also initiated the Interagency Mixed Exposures Research Group to encourage collaboration and consistency across governmental agencies regarding mixtures risk assessment. His publication record includes journal articles, book chapters and EPA guidance documents. His knowledge of both the toxicologic and statistical issues concerning the risk assessment of complex chemical exposures and his development of methods to assess mixture dose response and interaction effects have made him an international expert in this field. Rick is a member of the Society for Risk Analysis, the American Statistical Association and the Sierra Club.
In March of 1990, Glenn Rice was appointed to the position of Environmental Health Scientist with the U.S. Environmental Protection Agency’s Environmental Criteria and Assessment Office (now the National Center for Environmental Assessment Cincinnati Division (NCEA) in Cincinnati, OH. His research interest is human health risk assessment methods. He initially served as a member of the Cancer Risk Assessment Verification Endeavor (CRAVE Work Group). He has lead both a multimedia exposure assessment team in NCEA-CIN and a comparative risk assessment project team. He also served as acting science advisor for NCEA-Cincinnati Division for a year. In addition to co-authoring several peer-reviewed journal publications and book chapters, he is one of the primary authors of the EPA’s Mercury Study Report to Congress and EPA’s Chemical Mixtures Guidance. Glenn has served as the Chapter President of the Ohio Chapter for the Society of Risk Analysis. He holds a Master’s Degree in Microbiology from Miami University, as well as a BA in Biology and an AS in Chemistry from Thomas More College. Glenn and his wife, Nancy, are the proud parents of four children.
The registration fee is $249 before 10 November, or $279 on site. You do not need to register for the Annual Meeting to attend the workshop. Registration will be handled by
The event will be held 8am - 12pm on Sunday, 7 December 2003, at
The room for the event has not yet been determined; check with the hotel concierge. To reserve a room at the hotel, call 800-468-3571 before 10 November 2003. Be sure to identify yourself as a SRA Annual Meeting attendee to receive the SRA group rate of $135 per night (single or double occupancy) plus 12.5% tax. Cancellations must be made at least 48 hours in advance. See a description of the hotel at http://www.marriott.com/dpp/PropertyPage.asp?MarshaCode=BWISH.
More information can be obtained from Linda Teuschler teuschler.linda@epa.gov, telephone 513-569-7573, fax 513-569-7916.
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